Wednesday, March 18, 2020

COrona VIrus Disease - COVID

Continuo sem ver o que quero: desinfeção massiva.
A doença COVID-19 - COrona VIrus Disease
O vírus SARS-CoV-2 - SevereAcuteRespiratorySyndrome-COronaVirus-2


  • Correspondence
The proximal origin of SARS-CoV-2 Nature Medicine (2020)12407 AltmetricMetrics


Theories of SARS-CoV-2 origins

It is improbable that SARS-CoV-2 emerged through laboratory manipulation of a related SARS-CoV-like coronavirus. As noted above, the RBD of SARS-CoV-2 is optimized for binding to human ACE2 with an efficient solution different from those previously predicted7,11. Furthermore, if genetic manipulation had been performed, one of the several reverse-genetic systems available for betacoronaviruses would probably have been used19. However, the genetic data irrefutably show that SARS-CoV-2 is not derived from any previously used virus backbone20. Instead, we propose two scenarios that can plausibly explain the origin of SARS-CoV-2: (i) natural selection in an animal host before zoonotic transfer; and (ii) natural selection in humans following zoonotic transfer. 

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