COrona VIrus Disease - COVID

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A doença COVID-19 - COrona VIrus Disease

O vírus SARS-CoV-2 - SevereAcuteRespiratorySyndrome-COronaVirus-2

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• Correspondence

• Published: 17 March 2020

The proximal origin of SARS-CoV-2

• Kristian G. Andersen, 
• Andrew Rambaut, 
• W. Ian Lipkin, 
• Edward C. Holmes & 
• Robert F. Garry 

Nature Medicine (2020)Cite this article12407 AltmetricMetrics

• details

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Theories of SARS-CoV-2 origins

It is improbable that SARS-CoV-2 emerged through laboratory manipulation of a related SARS-CoV-like coronavirus. As noted above, the RBD of SARS-CoV-2 is optimized for binding to human ACE2 with an efficient solution different from those previously predicted7,11. Furthermore, if genetic manipulation had been performed, one of the several reverse-genetic systems available for betacoronaviruses would probably have been used19. However, the genetic data irrefutably show that SARS-CoV-2 is not derived from any previously used virus backbone20. Instead, we propose two scenarios that can plausibly explain the origin of SARS-CoV-2: (i) natural selection in an animal host before zoonotic transfer; and (ii) natural selection in humans following zoonotic transfer.